PHARMACOLOGY :
Amodis ® (Metronidazole), a nitroimidazole has an extremely broad spectrum antiprotozoal and antimicrobial activities, with high activity against anaerobic bacteria and protozoa. Amodis ® (Metronidazole) is usually completely and rapidly absorbed after oral administration. The half-life in plasma is about 8 hours. About 10% of the drug is bound to plasma proteins. Amodis ® (Metronidazole) penetrates well into body tissues and fluids. The liver is the main site of metabolism. Both unchanged Metronidazole and metabolites are excreted in various proportions in the urine after oral administration.
INDICATION :
All forms of amoebiasis (intestinal and extra-intestinal disease including liver abscess and that of symptomless cyst passers) Trichomoniasis Giardiasis Bacterial vaginosis Acute ulcerative gingivitis Anaerobic infections including septicaemia, bacteraemia, peritonitis, brain abscess, necrotising pneumonia, osteomyelitis, puerperal sepsis, pelvic abscess, pelvic cellulitis etc. Anaerobically-infected leg ulcers and pressure sores Acute dental infections (e.g. acute pericoronitis and acute apical infections) Surgical prophylaxis (prevention of postoperative
infections due to anaerobic bacteria, particularly species of bacteroides and anaerobic streptococci
Chronic symptomatic peptic ulcer disease (as an agent of triple therapy to eradicate H. pylori -the most important aetiological factor of peptic ulcer)
ADVERSE REACTION :
Metalic taste, furred tongue, nausea, vomiting, diarrhoea, drowsiness, rashes and mild reversible leucopenia may be observed during treatment.
DRUG INTERACTION :
Metronidazole interacts with warfarin, nicoumalone, phenytoin, phenobarbitone, fluorouracil, disulfiram, lithium, cimetidine etc.
PREGNANCY & LACTATION :
Not recommended during first & later trimesters. Breast feeding should be delayed until 48 hours
after discontinuing metronidazole in the mother.
STORAGE CONDITION :
Tablet: Store in a cool and dry place. Protect from light and moisture. Keep out of the reach of children.
Suspension: Store in a cool and dry place. Protect from light. Keep out of the reach of children.
Concomitant treatment of sexual consorts is recommended.
Dosage & Administration:
For detail please see the full prescribing information at bellow link:
http://www.squarepharma.com.bd/downloads/Amodis.pdf