Fixal Plus 60mg 1pcs

For the relief of symptoms associated with seasonal and perennial allergic complications in adults and children 12 years of age and older. Symptoms treated effectively include sneezing, rhinorrhea, itchy nose/ palate/ and/or throat, itchy/ watery/ red eyes, and nasal congestion.

It should be administered when both the antihistaminic properties of Fexofenadine Hydrochloride and the nasal decongestant properties of Pseudoephedrine Hydrochloride are desired.

Anti-histamine & decongestant

 

Pharmacology

Fexofenadine Hydrochloride is an antihistamine with selective peripheral H1 receptor antagonist activity. It does not cross the blood brain barrier.

Pseudoephedrine is an orally active sympathomimetic amine and exerts a decongestant action on the nasal mucosa. This is recognized as an effective agent for the relief of nasal congestion due to allergic rhinitis.

Pseudoephedrine is both an α-and β-adrenergic receptor agonist. It causes vasoconstriction via direct stimulation of α-adrenergic receptors of the respiratory mucosa. It also directly stimulates β-adrenergic receptors causing bronchial relaxation, increased heart rate and contractility.

The recommended dose is one tablet twice daily administered on an empty stomach with water for adults and children 12 years of age and older. It is recommended that the administration of this Tablet with food should be avoided.

One tablet once daily is recommended as the starting dose in patients with decreased renal function. This must be swallowed whole and never crushed or chewed.

Fexofenadine Hydrochloride and Pseudoephedrine Hydrochloride do not influence the pharmacokinetics of each other when administered concomitantly. However, co-administration of Fexofenadine Hydrochloride with either ketoconazole or Erythromycin lead to increased plasma concentrations of Fexofenadine.

This drug is contraindicated in patients with known hypersensitivity to any of its ingredients.

The reported side effects are insomnia, headache, nausea, dry mouth, dizziness, agitation, nervousness, anxiety, and palpitation etc.

Pregnancy: Category C. It should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

Lactation: Caution should be exercised when this drug is administered to nursing women.

Hyperthyroidism; ischaemic heart disease, arrhythmia or tachycardia; occlusive vascular disorders e.g. arteriosclerosis, hypertension or aneurysms; DM and closed-angle glaucoma; renal impairment, prostatic enlargement. Pregnancy; lactation.

For Fexofenadine: There is limited information, however, dizziness, drowsiness, and dry mouth etc. have been reported.

For Pseudoephedrine: headache, nausea, vomiting, sweating, thirst, tachycardia, pericardial pain, palpitations, difficulty in micturition, muscular weakness and tenseness, anxiety, restlessness, and insomnia etc have been reported.

Pediatric Uses: This drug is not recommended for pediatric patients under 12 years of age.

Storage Conditions

Store at a cool and dry place, protected from light & moisture. Keep out of reach of children.