Composition :
Losartan Potassium 25mg, 50mg & 100mg Tablet
Indications :
This tablet is indicated for the treatment of hypertension. It may be used alone or in combination with other antihypertensive agents.
This fixed dose combination is not indicated for initial therapy.
Dosage and administration:
The usual starting dose of Losartan is 50mg once daily, with 25mg used in patients with possible depletion of intravascular volume and patients with a history of hepatic impairment. Losartan can be administered once or twice daily at total daily doses of 25 to 100 mg. If the antihypertensive ef fect measured at through using once a day dosing is inadequate, a twice a day regimen at the same total daily dose or an increase in dose may give a more satisfactory response. Hydrochlorothiazide is ef fective in doses of 12.5 to 50mg once daily and can be given at doses of 12.5 to 25mg as this medicine.Or, as directed by the registered physician.
Side effects :
The most commonly reported adverse ef fects are abdominal pain, edema, palpitation, back pain, dizziness, cough, sinusitis, upper respiratory tract infections, rash, nausea, headache, bronchitis, pharyngitis.
Contraindications :
This medicine is contraindicated in patients who are hypersensitive to any component of this product. Because of the hydrochlorothiazide component, this product is contraindicated in patients with anuria, or hypersensitivity to other sulfonamide-derived drugs.
Precautions :
Thiazides should be used with caution in severe renal disease. A patient receiving this medicine should be told not to use potassium supplements or salt substitutes containing potassium without consulting the registered physician.
Use in pregnancy and Iactation :
This medicine is not generally recommended during pregnancy , except under exceptional circumstances. This medicine passes into breast milk. Consequently , breast-feeding is not recommended.
Drug interactions :
No significant drug-drug pharmacokinetic interactions have been found in interaction studies with hydrochlorothiazide, digoxin, warfarin, cimetidine and Phenobarbital. As with other antihypertensive agents, the antihypertensive effect of Losartan may be blunted by the non-steroidal anti-inflammatory drug indomethacin.
Packing :
Losardil-25 :4×14’s tablets inblister pack.
Losardil-50 :2×14’s tablets in blister pack.
Losardil-100 :2×14’s tablets in blister pack.